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Figure 2 Sotalol-induced prolongation of the action potential is
mediated in part via inhibition of IKr.
These data (illustrated in Figure 2) show that the amplitude of the
tail current activated after 40 ms, IKr, was
significantly reduced by 75ॠby sotalol. However, the
amplitude of the tail current elicited after 400 ms, comprising
both IKs and IKr, was only
reduced by 39ॠreflecting the contribution of IKr
to this current.
These data suggest the the effects of sotalol
are mediated via and effects on IKr rather
than on IKs.
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